In addition to Teamfight Tactics, the changes in patch 10.12 also have a huge impact on the meta of League of Legends. Specifically, these adjustments relate to the entire map, runes, and other summoner spells.
Here are the most notable changes in 10.12:
Summoner Spells

• Ghost: Movement speed bonus changed from 28-45% to 20-40%. Removed speed increase duration. Cooldown increased from 180 to 210 seconds. Duration increased from 4-7 seconds (based on level) each time participating in a kill.
Runes

Protector:
• Range increased from 175 to 350.
• Removed activation by any damage; now activates when taking 75-200 damage in the last 2.5 seconds or when taking damage with lethality.
• Shield increased from 70-150 to 80-200.
• Removed movement speed increase.

Predator:
• Cooldown reduced from 150-100 seconds to 100-70 seconds.
• Damage changed from 60-180 (+0.4 bonus AD) (+0.25 AP) to 30-90 (+0.2 bonus AD) (+0.1 AP).
• Can now be used immediately when the match starts.
• Removed the movement speed increase of 67.5% that gradually decreased to 45%, replaced by a gradual increase to 45% movement speed over 1.5 seconds when approaching enemy champions.
• No channeling time required anymore.
• Bonus damage only applies when attacking enemy champions.
• Duration reduced from 15 to 10 seconds.

Tenacity:
• Gain 10% crowd control resistance and slow resistance, increasing to 30% based on % health lost (max effectiveness when below 30% health).

Bloodline:
• Now can track effects on the status bar.

Approach Velocity:
• Gain 7.5% movement speed when approaching an enemy in crowd control, doubling the speed if the player themselves is crowd controlling the enemy.
Map Changes:
Wind Dragon:
• Movement speed in the acceleration zone increases by 35% when out of combat. The Bright Blossom now has additional spawn near the side entrance, also available in the bush on the third lane.
Fire Dragon:
• Additional Explosive Seeds near the Spirit Toad, with additional Explosive Seeds near the side entrance.
Plans to nerf some champions such as Varus, Yasuo, Cassiopeia, Fiddlesticks, and Trundle. Buffing champions like Volibear, Akali, Senna (ADC), Xayah, Brand, and Viktor.