Diana
With the removal of the Lunar trait, Riot Games has transformed Diana into a Spirit champion in Teamfight Tactics Set 4.5. This change significantly weakens Diana, making her arguably the weakest Assassin in Set 4.5. The inability to “hyper-roll” her to 4 stars has rendered the hyper-roll strategy for Diana less optimal. A slight increase in attack speed from the Spirit trait cannot compensate for the lost stats of Diana.

The advice for players is not to place too much faith in Diana in the upcoming Set 4.5. If you need a champion to activate the Spirit trait or Assassin class, then Diana is an acceptable choice. However, you should not invest too many items into this champion.
Zed
Moving into Set 4.5, Zed has lost the defensive capability from the Shadow system. In exchange, Zed receives increased damage and lifesteal from the Butcher system. This means Zed must be at a high level with enough powerful items to deal effective damage. If you cannot successfully hyper-roll Zed to 3 stars, this champion will be extremely weak in the late game.

Remember, Kayn and the Shadow system are also on the list of content removed in Set 4.5. Therefore, the “insurance” for late game with a composition centered around Zed is no longer available. If you have an early Elite Zed or a strong Butcher lineup, only then should you use this unit. Thus, Zed is no longer an “auto rank-up” option but will rely heavily on “luck” to be strong.
Kindred
The introduction of the new system – Reaper has made Kindred significantly weaker in the mid-game but quickly stronger in the later stages. At levels 6-7, it will be challenging to activate the effect from the Reaper system, thus reducing Kindred’s physical damage considerably. Meanwhile, Kindred can still deal a sufficient amount of physical damage while being a Hunter.

By the late game, Kindred, when combined with Xayah and Kayle, can easily obliterate enemy teams with their devastating critical damage. In fact, Kindred can completely cover the weaknesses of Xayah and Kayle with their strong damage output. Overall, Kindred will be much stronger in the late game during Set 4.5.
Morgana
The upcoming Set 4.5 of Teamfight Tactics can be said to have completely changed the nature of Morgana. This champion will become a true tank thanks to significant buffs to her defensive stats from Riot Games. Moreover, Morgana’s skill now includes a damage reduction effect for opponents, allowing her to be effectively utilized in various team compositions.

Essentially, the “new” Morgana is no longer heavily dependent on the Enlightened composition. Being placed in the frontline will help Morgana somewhat solve her energy issues. The only advice for players to use Morgana effectively in Set 4.5 is to equip this unit with defensive items rather than damage items.