Gunner
Among the main systems of Teamfight Tactics Season 7.5, the Gunner is currently showing extreme weakness. The biggest weakness of the Gunner is that the carry – Nomsy is too reliant on luck to have the effects of this system. Therefore, in many cases, you cannot use the Gunner composition even when you have the appropriate items.

In the upcoming Patch 12.21, Riot Games will buff the Gunner with changes to the damage at the 4 and 6 champion thresholds. This encourages players to utilize higher thresholds of Gunners and strengthens the playstyle revolving around Graves in the late game.
Xayah – Syndicate
With the dominance of the Dragon God composition in recent times, players have gradually realized the weaknesses of 4-cost champions in Teamfight Tactics. Essentially, 4-cost champions in Season 7.5 tend to be significantly weaker compared to 6 or 7-cost Dragon God champions. Consequently, during the late game, 4-star champions fall short in both damage and durability.

Specifically, the Xayah – Syndicate composition has weakened significantly recently. In Patch 12.21, Riot has decided to buff Xayah at all levels, enabling this champion to deal much better damage. This is a necessary move as the Xayah – Syndicate composition is severely lacking in damage.
Spellcaster – Ascendant
In Season 7.5 of Teamfight Tactics, the Ascendant trait has been revamped and has become much more balanced. Additionally, having a champion that deals good magic damage early and mid-game, like Lux, has made the Ascendant composition very popular.

In the upcoming Patch 12.21, Riot continues to show favoritism towards Ascendant by significantly buffing Lux. Specifically, the damage from Lux’s skill will be increased against targets in a straight line. These upgrades are essential for the Ascendant trait to dominate the meta.
Conclusion
Essentially, the changes made by Riot in Patch 12.21 are not as significant as reworking some champions or traits. Instead, Riot focuses on directly buffing compositions that are currently underrated or too weak in the previous patch. If you are looking for a new meta in Patch 12.21, the compositions mentioned above are reasonable choices.